Many people with multiple sclerosis (MS) feel fatigued. This feeling of tiredness can make everyday tasks more difficult.
There are medicines that can ease MS-related fatigue. These include Provigil, methylphenidate, and amantadine.
Efficacy
Fatigue is a common symptom of multiple sclerosis (MS). It can interfere with physical, mental, and emotional functions.
There are several ways to treat fatigue, including cognitive behavioral therapy and a sleep-promoting medicine called modafinil. However, these treatments are not always effective.
A Phase 3 trial (NCT03185065) is currently underway to compare the effects of Provigil, methylphenidate, and amantadine on fatigue in MS patients. It is not recruiting new participants at this time.
Safety
Fatigue is a common problem in people with multiple sclerosis (MS). It may not get better with sleep, and it can make it hard to do daily activities.
If you have MS and fatigue, talk to your doctor about treatments. They may suggest changes in your diet or other ways to manage fatigue.
A medicine used to treat symptoms of narcolepsy also can help ease fatigue in some people with MS. It’s called modafinil.
Researchers tested this medicine on 72 patients with severe fatigue and MS. They gave them a placebo or varying dosages of modafinil.
Side Effects
Modafinil (Provigil) is a wakefulness-promoting medicine that is approved to treat excessive daytime sleepiness caused by narcolepsy, obstructive sleep apnea, and shift work disorder. Modalert 200 Online may also be used to treat fatigue in patients with MS. A “wakefulness-promoting agent” is another name for Waklert Tablet. This drug aims to lessen drowsiness brought on by a variety of disorders, such as narcolepsy, sleep apnea, and shift work sleep disorder.
Fatigue is a common symptom of multiple sclerosis and is often difficult to manage. However, a comprehensive fatigue management plan can be effective in reducing fatigue and improving quality of life.
Several medications are used to treat fatigue in MS. These include amantadine, methylphenidate, and modafinil.
The results of a study of these medicines show that they do not improve MS fatigue and are associated with more side effects than placebo. This is a very important finding for doctors who often prescribe these medicines to their patients.
This study was a 9-week, single-blinded pilot trial of modafinil in 72 adult patients with relapsing-remitting MS or primary progressive MS who had not been treated for fatigue prior to the study. The participants completed fatigue questionnaires and a visual analog scale measuring the degree of fatigue.
Dosage
There are several different medications that can be used to treat fatigue in multiple sclerosis. These include Modafinil (Provigil), methylphenidate, and ADS-5102 (a delayed-release formulation of amantadine).
In addition, there are some lifestyle changes that can help to manage fatigue in MS. For example, some people may benefit from avoiding caffeine and other stimulants, especially before bedtime.
Modafinil is a medicine that promotes wakefulness. It is licensed for treating narcolepsy, but it has also been shown to be effective in some people with MS.
Fatigue is a common problem for people with MS. Many of these patients find it difficult to control their fatigue and are often frustrated by their symptoms. It is important to speak with your doctor about your options for treatment.